vicissitude

Từ điển American Heritage Dictionary 4th

vi·cis·si·tude (vĭ-sĭsʹĭ-to͞od', -tyo͞od')n.
1.
a. A change or variation.
b. The quality of being changeable; mutability.
2. One of the sudden or unexpected changes or shifts often encountered in one's life, activities, or surroundings. Often used in the plural. See Synonyms at difficulty. [Latin vicissitūdō, from vicissim, in turn, probably from vicēs, pl. of *vix, change. See weik-² in Indo-European Roots.]